HOMEWORK 10
BIOL/CHEM 5310
due Tuesday, December 3, 2002


1. VVP , Chapter 3, page 75, problems 1, 2, 3

2. VVP , Chapter 23, page 771, problems 1, 2, 4, 5, 6, 7, 9

3. Draw the chemcial structure of an A:T base pair, showing the deoxyriboses, the bases
and the H-bonds. Indicate the major groove and the minor groove. Identify an H-bonding group in each groove.
4. Use the table on the next page to calculate the relative stabilities (DG values) of the 3 DNA duplexes shown below. Does the DG vary with the GC content as expected ? (Explain)

Duplex a)

5'-ATGAAAAGTT
3'-TACTTTTCAA



Duplex b)

5'-ATGCTACCAA
3'-TACGATGGTT



Duplex c)

5'-ATGGGCCCCG
3'-TACCCGGGGC