HOMEWORK 10
BIOL/CHEM 5310
due Tuesday, December 3, 2002
1. VVP , Chapter 3, page 75, problems 1, 2, 3
2. VVP , Chapter 23, page 771, problems 1, 2, 4, 5, 6, 7, 9
3. Draw the chemcial structure of an A:T base pair, showing the deoxyriboses, the bases
and the H-bonds. Indicate the major groove and the minor groove. Identify an H-bonding group in each groove.
4. Use the table on the next page to calculate the relative stabilities (DG values) of the 3 DNA duplexes shown below. Does the DG vary with the GC content as expected ? (Explain)
Duplex a)
5'-ATGAAAAGTT
3'-TACTTTTCAA
Duplex b)
5'-ATGCTACCAA
3'-TACGATGGTT
Duplex c)
5'-ATGGGCCCCG
3'-TACCCGGGGC