Conservation in nuoA Back to subunit list
The membrane sector of E. coli Complex I is shown with each of the 6 subunits colored a different color. The peripheral arm and subunit H of the membrane arm are missing.

 nuoL  ND5  :L
 nuoM  ND4  :M
 nuoN  ND2  :N
 nuoK  ND4L  :K
 nuoJ  ND6  :J
 nuoA  ND3  :A
Subunit A is colored according to conservation. Magenta is most conserved, cyan is least conserved. Several lipids, detergents and internal water molecules are shown in space filling.

Isolated view of subunit A. (Residues 44-60 were not resolved in the crystal structure.)

G58 in nuoA is not visible   
A60 in nuoA is not visible     
M73 in nuoA    Undo   
D79 in nuoA    Undo

Atoms within 6 Å of subunit A are shown in cpk according to the coloring scheme:

 nuoN  ND2  :N
 nuoK  ND4L  :K
 nuoJ  ND6  :J
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Most conserved residues of subunit A .

Glu 81, in the proton channel, colored lime.

Efremov RG, Sazanov LA.
Structure of the membrane domain of respiratory complex I.
Nature. 2011 Aug 7;476(7361):414-20.PubMed)

pdb number (3rko)