Conservation in nuoM Back to subunit list
The membrane sector of E. coli Complex I is shown with each of the 6 subunits colored a different color. The peripheral arm and subunit H of the membrane arm are missing.
 nuoL  ND5  :L
 nuoM  ND4  :M
 nuoN  ND2  :N
 nuoK  ND4L  :K
 nuoJ  ND6  :J
 nuoA  ND3  :A
         
Subunit M is colored according to conservation. Magenta is most conserved, cyan is least conserved. Several lipids, detergents and internal water molecules are shown in space filling.

Isolated view of subunit M.
L183 in nuoM (L158)    Undo 
L190 in nuoM (I165)    Undo  
L148 in nuoL    Undo   
Y158 in nuoL    Undo  
Atoms within 6 Å of subunit M are shown in cpk according to the coloring scheme:
 nuoL  ND5  :L
 nuoN  ND2  :N
         
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Conserved residues of M. Glu 144, Lys 234,Lys 265, His 322, Glu 407, in the proton channel of nuoM, colored lime.


Efremov RG, Sazanov LA.
Structure of the membrane domain of respiratory complex I.
Nature. 2011 Aug 7;476(7361):414-20.PubMed)

pdb number (3rko)