Left-handed β-helix UDP-GlcNAc acyltransferase (LpxA)
This enzyme catalyzes a step in Lipid A biosynthesis, a component of the outer membrane in Gram-negative bacteria. It is formed from 3 identical subunits, and the active site appears to be found between subunits. Each subunit contains a left-handed β-helix with 3 faces made up of short, parallel β-strands. 3 copies of a peptide inhibitor - colored green- identify the likely active sites.
2aq9 (PDB) |