|
Cellular Retinol BindingProtein Cartoons view of Cellular Retinol Binding Protein, an up-an-down 10-stranded beta barrel. There are 2 alpha-helices, colored magenta, between strands 1 and 2, which close off one end of the barrel. The retinol binds inside the barrel. The H-bonds are shown, indicating that one edge is not sealed (between 2 green strands). Notice that the 10th strand ends up next to the first strand. A spacefilling view shows that the retinol is totally buried. (Remember, it is a nonpolar molecule.) The helices are colored magenta. Now click button 1 to see how the helices close one end of the barrel.
Cowan, S. W., Newcomer, M. E., Jones, T. A. Crystallographic studies on a family of cellular lipophilic transport proteins. J Mol Biol 230 pp. 1225 (1993) (PubMed) 1crb (PDB) |