Leucine zipper protein

This is the leucine zipper segment from GCN4, the yeast transcription factor. It is a 2-stranded, parallel coiled-coil. The leucines are colored red. Notice that they are side-by-side. One of the interactions uses 4 leucines (i+7, i+8).



O'Shea, E. K., Klemm, J. D., Kim, P. S., Alber, T.: X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254 pp. 539 (1991)
(PubMed)

2zta (PDB)