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Gly-X-X-Gly interface Glycophorin is a dimeric membrane protein. The two subunits interact in the membrane via two transmembrane alpha-helices. Each helix contains the G-X-X-G sequence motif. The presence of the glycines, lacking side chains, allows the helices to form very close contacts with each other. This is a common sequence motif in membrane proteins. The Glycine residues at the interface of the helices are colored green. Note: Since this structure was determined by NMR, the Hydrogens are shown, colored white in the CPK scheme. A transmembrane helix dimer: structure and implications. (PubMed) 1afo (PDB)
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