| Leptin
Leptin is a hormone involved in appetite. How many cross-over connections are there? (Note: not all amino acids are shown in this model, so follow the colors.)
Zhang, F., Basinski, M. B., Beals, J. M., Briggs, S. L., Churgay, L. M., Clawson, D. K., DiMarchi, R. D., Furman, T. C., Hale, J. E., Hsiung, H. M., Schoner, B. E., Smith, D. P., Zhang, X. Y., Wery, J. P., Schevitz, R. W.: Crystal structure of the obese protein leptin-E100. Nature 387 pp. 206 (1997) 1ax8 (PDB) |
Growth hormone
How many cross-over connections are there? Is the topology of growth hormone the same as leptin? How do the two hormones differ? de Vos, A. M., Ultsch, M., Kossiakoff, A. A.: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255 pp. 306 (1992) 3hhr (PDB) |