| Myoglobin | Click the buttons to change the display |
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Cartoons view of Myoglobin, with its 8 helices. N-terminus is colored blue, C-terminus is red. Notice that all helices pack against other helices with a larger crossing angle, except the last two, that pack in an anti-parallel fashion (coiled-coil). Is this right-handed or left-handed? Where does the heme fit?
Myoglobin is a muscle protein that binds Oxygen by using a heme group. This heme is found between 2 helices. The helices of myoglobin are generally named A-H.
The side chains are tightly packed against each other. The edge of the heme is visible, but not the path to the Fe. How does the Oxygen gain entrance?
Structure of Myoglobin Refined at 2.0 Angstroms Resolution. II. Structure of Deoxymyoglobin from Sperm Whale Takano, T. (1977) J.Mol.Biol. 110: 569 PubMed) 4mbn(PDB) |