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SecA bound to the LamB signal peptide SecA is an ATPase that that uses the energy of ATP hydrolysis to help export proteins across a bacterial plasma membrane. Here it is colored blue, and is bound to the signal peptide of LamB, an outer membrane protein in green. The structure was determined by NMR, and is rather large, about 200 kD. Initially only one model is shown, but after 10 seconds, all 10 models are shown, indicating a range of conformations consistent with the data. One region in particular appears flexible, and would be difficult to determine by crystallography Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR.(PubMed) 2vda (PDB) |
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