Aspartate aminotransferase
Mostly parallel beta-strands in an open twisted sheet
This enzyme transfers the amino group from aspartic acid
L-aspartate + 2-oxoglutarate =
oxaloacetate + L-glutamate
Jeffery, C. J., Barry, T., Doonan, S., Petsko, G. A., Ringe, D.: Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase. Protein Sci 7 pp. 1380 (1998)
(PubMed)
1yaa (PDB) |
D-amino acid aminotransferase
2 beta-sheets, mostly antiparallel
This enzyme transfers the amino group from D-amino acid:
D-alanine + 2-oxoglutarate =
pyruvate + D-glutamate
Peisach, D., Chipman, D. M., Van Ophem, P. W., Manning, J. M., Ringe, D.: Crystallographic study of steps along the reaction pathway of D-amino acid aminotransferase. Biochemistry 37 pp. 4958 (1998)
(PubMed)
3daa (PDB) |