Aspartate aminotransferase

Mostly parallel beta-strands in an open twisted sheet

This enzyme transfers the amino group from aspartic acid

L-aspartate + 2-oxoglutarate =
oxaloacetate + L-glutamate



Jeffery, C. J., Barry, T., Doonan, S., Petsko, G. A., Ringe, D.: Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase. Protein Sci 7 pp. 1380 (1998)
(PubMed)

1yaa (PDB)

D-amino acid aminotransferase

2 beta-sheets, mostly antiparallel

This enzyme transfers the amino group from D-amino acid:

D-alanine + 2-oxoglutarate =
pyruvate + D-glutamate


Peisach, D., Chipman, D. M., Van Ophem, P. W., Manning, J. M., Ringe, D.: Crystallographic study of steps along the reaction pathway of D-amino acid aminotransferase. Biochemistry 37 pp. 4958 (1998)
(PubMed)

3daa (PDB)