Trypsin

The catalytic triad is in blue. The fold of the protein has 2 barrels composed of beta-strands. The catalytic site is at the interface of the 2 domains.


RJ Fletterick & ME McGrath (PubMed)

1ane (PDB)

Subtilisin

The catalytic triad is in blue. The fold of the protein has a parallel beta-sheet in the center with alpha-helices on both sides. The catalytic site is at the C-terminal ends of the beta-sheet.


Alden, R. A., Birktoft, J. J., Kraut, J., Robertus, J. D., Wright, C. S.: Atomic coordinates for subtilisin BPN' (or Novo). Biochem Biophys Res Commun 45 pp. 337 (1971) (PubMed)

1sbt (PDB)