Human growth hormone and its receptor
This is an example of a non-symmetrical oligomer. There are 2 copies of the receptor and and a single copy of the growth hormone. Similar regions on the receptors bind to two distinct sites on the hormone. The hormone is a four-helix bundle with 2 cross-over connections. The receptor is a two-domain protein. Think about it in terms of dominant-negative mutations.
3hhr (PDB) |