| Complementarity of Interleukin-4 and its receptor | |
|
Cartoons view of Interleukin-4, a 4-helix bundle in blue, with its receptor in green.
At the interface, Arg and Lys are colored blue, Asp and Glu are colored red, polar residues are colored yellow, and nonpolar residues are colored gray.
Some of the hydrogen bonds at the interface of interleukin and its receptor are shown in yellow. Then interleukin alone is shown, followed by its receptor alone. 1iar (PDB) Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Hage, T., Sebald, W., Reinemer, P., (1999) Cell 97: 271-281 (PubMed)
|