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Lactate Dehydrogenase The apoenzyme is shown (lacking ligands). When the substrates bind, the conformation changes. The green helix and loop will enclose the substrate. Abad-Zapatero, C., Griffith, J. P., Sussman, J. L., Rossmann, M. G.: Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. J Mol Biol 198 pp. 445 (1987) 6ldh (PDB) |
Lactate Dehydrogenase with bound ligands
Pyruvate is colored yellow and NAD is colored blue. Notice that the green loop in the folds around the NAD, and the green helix in the lower left becomes broken as it closes on the substrates. White, J. L., Hackert, M. L., Buehner, M., Adams, M. J., Ford, G. C., Lentz Jr., P. J., Smiley, I. E., Steindel, S. J., Rossmann, M. G.: A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. J Mol Biol 102 pp. 759 (1976) (PubMed) 3ldh (PDB) |