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6-bladed beta-propeller protein: Neuraminidase Cartoon view of neuraminidase, an enzyme with 4 identical subunits, each a 6-bladed beta-propeller. Notice that one strand at the N-terminus, colored blue, forms an antiparallel beta-sheet with 3 strands from the C-terminus, colored red. The active site of such a protein is typically formed by the loops connecting the two interior beta-strands. Initially they are ribbons, but will eventually become spacefilling, colored purple. N-acetylglucosamine in spacefilling shows where the active site is. A single blade of the propeller, consists of 4 anti-parallel beta-strands. The first strand starts in the center of the protein and the fourth strand is at the outside edge of the protein.
1a4q (PDB) Taylor, N. R.,et al.: Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. J Med Chem 41 pp. 798 (1998) (PubMed)
Varghese JN, Laver WG, Colman PM. |