Loss of antioxidant activity of human PRDX5 C47S mutant is due to the replacement of the catalytic Cys by a Ser and conformational changes did not lead to the release of the benzoate ion.

Crystal Structure of the C47S Mutant of Human Peroxiredoxin 5. Evrard, C., Smeets, A., Knoops, B., Declercq, J.P., (2004) J. Chem. Cryst. 34: 553 (PubMed ID is not available)

PDB Number:1URM (PDB)