C2H2 Zinc Finger protein Snail1 by Importin Beta

Snail contributes to the epithelial mesenchymal transition by suppressing E cadherin in transcription processes. The snail C2H2 type Zinc Finger domain functions both as a nuclear localization signal which binds to importin beta directly and as a DNA binding domain.  The Snail Importin Beta complex contains 5 domains: One in the Importin Beta, and the other four in the zinc finger snail.