C2H2 ZF Snail1 Importin Beta Complex


The Zinc Finger domain is able to bind to the Importin Beta complex by  the ZF1 domain binding to the HEAT10 domain of Importin Beta and the ZF2-ZF3 domains are captured in the inner surface of the importin beta . 


3W5K (PDB)

 Importin-beta and SREBP-2 complex

The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through a direct interaction of its helix-loop-helix leucine zipper domain with importin-beta. The crystal structure of importin-beta complexed with the active form of SREBP-2. Importin-beta uses characteristic long helices like a pair of chopsticks to interact with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a pseudo-twofold symmetry on its surface structure so that it can accommodate a symmetric dimer molecule.


1UKL (PDB)