Mutations in the PARK2 (parkin) gene are stated to cause an autosomal recessive form of Parkinson's disease. The parkin protein is known as a RING-in-between-RING E3 ubiquitin ligase and this depicted crystal structure is the full-length rat parkin.
Authors:
Trempe, J.F., Sauve, V., Grenier, K., Seirafi, M., Tang, M.Y., Menade, M., Al-Abdul-Wahid, S., Krett, J., Wong, K., Kozlov, G., Nagar, B., Fon, E.A., Gehring, K.
Title:
Structure of parkin reveals mechanism for ubiquitin ligase activation.
Journal (PubMed)
PDB ID (PDB)