RING0 obstructs the ubiquitin acceptor site Cys(431) in RING2, whereas a repressor element of parkin is able to bind RING1 and block its E2-binding site.
Authors:
Trempe, J.F., Sauve, V., Grenier, K., Seirafi, M., Tang, M.Y., Menade, M., Al-Abdul-Wahid, S., Krett, J., Wong, K., Kozlov, G., Nagar, B., Fon, E.A., Gehring, K.
Title:
Structure of parkin reveals mechanism for ubiquitin ligase activation.
Journal (PubMed)
PDB ID (PDB)