B-catenin interaction with APC

B-catenin interacts with the tumor suppressor gene product Adenomatous Polyposis Coli (APC) that is associated with familia and sporadic colorectal cancer.

The binding of APC residues is almost identical to the interactions that Tcf makes with b-catenin in this part of the armadillo repeats. Acidic residues of APC in red and basic residues in black. The phosphorylated APC 20 amino acids repeats (salmon) covers almost the entire structural grove of b-catenin (residues 145-665 - excluding the loop in R10). Spacefilling view of APC (yellow) interacting with b-catenin (grey).

Crystal structure of a beta-catenin/APC complex reveals a critical role or APC phosphorylation in APC function.
Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W.
Mol.Cell (PubMed)

1TH1 (PDB)