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Crystal structure of AcrB multidrug efflux pump Structure related to the function of AcrB.


Protomer structure complexed with bile acid which is the natural substrate for the AcrB.
 
ASP407, ASP 480 and Lys 940; Essential residues to the function of AcrB. Potential candidates for proton translocation.

Mol Membr Biol. 2008 Dec;25(8):677-82
The structure of the efflux pump AcrB in complex with bile acid.
Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K. (PubMed)

2W1B (PDB)

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