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Residues interacting with MBX2931 inhibitor in
the deep binding pocket of the monomer of the AcrB trimer. Binding
of the inhibitor molecules is mainly achieved by aromatic stacking
interactions and polar interactions by the indicated side chains.
MBX reach deep into the pocket creating stable interactions than
monocyclin or doxorubicin. Authors- Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS,
Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM,
Opperman TJ Title- Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. (2015) Sci Rep 5: 15493-15493 (PubMed) 5ENP (PDB) |