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This PIP box is shown in orange, the hydrophobic pocket that
binds the PIP boxes is shown in white. For reference on the back
of the protein, the Lys-164 that can be ubiquitinated is shown
in black.
Zoomed
in view of the hydrophobic pocket and the Polymerase η
interaction. Notice that the Met-701 interacts with the
hydrophobic pocket of PCNA, which has never been seen in PIP box
interactions before. This residue has been shown to be important
in modulating binding affinity of Pol η to PCNA, so that it
avoids competition with the less error-prone DNA polymerases. |