SIRT1/Activator/Inhibitor Complex in cartoon visualization

Secondary structure is represented in cartoon visualization in group color.

The founding member of the mammilian family of seven NAD (+)-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N-terminal region in shows in blue and C-terminal regions that shows in red . Also, the enzyme ‘deacetylase sirtuin 1,’ usually reverses the acetylation of PTEN. This processes also helps in decreasing the phosphorylation activity of PTEN and in the process reduce the progression of cancer or suppress tumors.

Citation
(PubMed)

4ZZI (PDB)

Crystal structure of human PCAF bromodomain in complex with acetyllysine

Secondary structure is represented in cartoon visualization that alpha helicies are pink, beta sheets are yellow, and regions without secondary structure are white. The wireframe shows one unique ligand ALY.

The acetylation of PTEN is triggered by growth factors and the acetylation takes place on K128 and K125 and the process is catalysed by the ‘acetyltransferase 2B enzyme (PCAF and is also called KAT2B). The residues that are usually targeted for acetylation usually lie in the catalytic area. This means that the acetylation process usually reduces the catalytic activity of PTEN and also affects the interaction between PTEN and its binding partners.


Citation (PubMed)

5FE0(PDB)

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