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| Pc monomers form a dimer. More careful examination of the dPC structure demonstrated the possibility of a chromodomain dimer that can account for the binding specificity of dPC.
The two chromodomains of dPC in the dimer interact by forming intermolecular hydrogen bonds between the main-chain atoms of Leu 64 and Arg 66 Min J, Zhang Y, and Xu R. 2003. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes & Development. 17(15):1823-8. (PubMed) 1PFB (PDB) |