The outer membrane of mitochondria (MOM) contains three integral membrane protein families which involves VDAC.

A variety of functions have been ascribed to the VDAC isoforms among which the direct coupling of the mitochondrial matrix to the energy maintenance of the cytosol seems to be the most general function.

The final protein structure contained all residues with the N and
C termini of the protein oriented to the same side of the barrel.

Cα secondary chemical shifts and slow hydrogen-deuterium exchange of amide protons revealed the topology of 19-strands with 65 interstrand NOEs unambiguously determining the register of all 19-strands. At the N terminus, a combination of NMR parameters identified an α-helix that binds to the barrel wall.

Structure of the human voltage-dependent anion channel.

Bayrhuber M1, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, Zeth K.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15370-5. doi: 10.1073/pnas.0808115105. Epub 2008 Oct 1.  (PubMed)

2JK4 (PDB)