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GSK-GKRP changes upon binding


Space-filling view of GCK-GKRP. Space-filling representation of the complex with GCK depicted in pink and GKRP in red.

N- and C-termini of GKRP are disordered.
GKRP termini remain disordered and become more fixed upon GSK binding. The first amino acid on both termini are colored cyan, the second amino acid is shown in blue.


N- and C-termini of GCK are disordered.
GSK also have disoredered regions at C- and N-termini that show increased order after binding to GKRP.

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Beck T, Miller BG

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein. Biochemistry 2013 (PubMed)

4LC9(PDB)