Changes in the β2-tubulin nucleotide site upon GDP/GTP exchange.


The T3 loop (β96–β102) (colored cyan), Asp β69 in T2 (β68–β70) (colored dark green), and residues β179–β180 in T5 (β171–β181) (colored light green) are shown as a stick model together with Tyr β224 in the central helix (β224–β243) (colored red). The GDP molecule is shown in orange.


Agata Nawrotek, Marcel Knossow and Benoît Gigant
The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J. Mol. Biol. (2011) (PubMed)

PDB ID : 3RYI (PDB)