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| Sav18662 from Staphylococcus aureus It is an ABC exporter with an outward-facing confirmation. This is a homodimer with ADP bound. The NBDs are linked to the TMDs in a single protein. Structure of a bacterial multidrug ABC transporter. Dawson, R.J.P., K.P. Locher. 2006(PubMed) 2HYD(PDB) |
TM287/288 from Thermotoga
maritima This is a heterodimer in an inward-facing conformation. It is bound by ANP. The hydrolysis of ATP in the outward-open conformation results in the reorientaion of TMDs, leading to the inward-open conformation where substrate and ATP binding take place.Compared with importers, the crystal structures of exporters shed less light on the interplay between the binding of transported substrates, the conformational change in the TMDs, the binding and hydrolysis of ATP, and the release of phosphate and ADP.
Crystal structure of a heterodimeric ABC transporter in its inward-facing confirmation. Hohl, M., C. Briand, M.G.Grutter, and M.A. Seeger. 2012(PubMed) 3QF4(PDB) |