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CmeB - Chain A, Access/Binding Conformation CmeB, PDBID 5LQ3, is a multidrug efflux pump found in Campylobacter jejuni. CmeB is one piece of a tripartite efflux system, which consists of (1) inner-membrane pump CmeB, (2) periplasmic adaptor CmeA, and (3) outer-membrane channel CmeC. Note: both pumps belong to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family. C. jejuni is the causative agent of enterocolitis, an infection which can trigger a severe autoimmune response and result in Guillian-Barre syndrome. The CDC has listed drug-resistant Campylobacter as a serious threat. Citation (Nature) 5LQ3 (PDB) |
MtrD - Chain A, Access/Binding Conformation MtrD, PDBID 4mt1, is a multidrug efflux pump found in Neisseria gonorrhoeae. Like CmeB, MtrD also part of a tripartite efflux system, which consists of (1) inner-membrane pump MtrD, (2) periplasmic adaptor MtrC, and (3) outer-membrane channel MtrE. Note: MtrD is also powered by a proton-relay network facilitated by charged residues D405, D406, and K948. N. gonorrhoeae is the causative agent of gonorrhea, an unpleasant sexually-transmitted disease. It is one of the oldest described diseases. Currently there is only one treatment available to treat drug-resistant gonorrhea. Citation (Pubmed) 4MT1 (PDB) back
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