The Drosophila Dopamine Transporter is a transmembrane protein, and a sodium-coupled neurotransmitter symporter. Its alpha helix core is amphipathic; the hydrophobic sides of the helices interface with the lipid membrane, while the hydrophilic sides create a relatively polar binding pocket in the protein's core.

Antidepressants that target DATs work by inhibiting their Dopamine (DOP) transport activity, thereby preventing DOP reuptake. This protein was co-crystallized with nortriptyline, an antidepressant. Nortriptyline blocks dDAT's drug-binding pocket and locks the protein in its outward-facing conformation.

RCSB PDB-ID: 4m48 (PDB)