FA2 in Human Complex I

Conservation in subunit FA2

Human Complex I is shown with each of the 45 subunits colored a different color. The prosthetic groups, including FMN, FeS clusters, quinone, NADP+ and lipids are shown in space filling, colored by cpk.

Subunit FA2 is colored according to conservation. Magenta is most conserved, cyan is least conserved.

Isolated view of subunit FA2 (chain F).

K45 in FA2 Undo
E57 in FA2 Undo

Atoms within 6 Å of subunit FA2 are shown in cpk according to the coloring scheme:

FS1 nuoG :M

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Protein wireframe   Protein cpk
Protein cartoon   Colored by sec. structure
Rainbow color: N-term-blue, C-term-red
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To show the atoms that contact residue 377 of NDUFV1 (:A),first select "color all" above, then type this: select within (6.0, 377:A); cpk only; display selected; center selected; zoom 1000; select 377:A; color white

Architecture of Human Mitochondrial Respiratory Megacomplex I₂III₂IV₂.
Guo R, Zong S, Wu M, Gu J, Yang M.
Cell. 2017 Sep 7;170(6):1247-1257.e12. doi: 10.1016/j.cell.2017.07.050.(PubMed)

pdb ID (5xtd)