Conservation in subunit FV1 (nuoF) Back to subunit list
Human Complex I is shown with each of the 45 subunits colored a different color. The prosthetic groups, including FMN, FeS clusters, quinone, NADP+ and lipids are shown in space filling, colored by cpk.

Subunit FV1 is colored according to conservation. Magenta is most conserved, cyan is least conserved.

Isolated view of subunit FV1.

R128 in FV1    Undo  (R102)
R199 in FV1    Undo   (T173)
E377 in FV1    Undo    (E349)
R386 in FV1    Undo   (R358)
Atoms within 6 Å of subunit FV1 are shown in cpk according to the coloring scheme:
 FV2  nuoE  :O
 FV3    :K
 FS1  nuoG  :M
 FS4    :L
         
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Protein wireframe   Protein cpk
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Atoms within 8 Å of E377 are shown. E377 of NDUFV1 and Arg200 of NDUFS1 (nuoG) and one FeS cluster are shown in CPK


Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Guo R, Zong S, Wu M, Gu J, Yang M.
Cell. 2017 Sep 7;170(6):1247-1257.e12. doi: 10.1016/j.cell.2017.07.050.(PubMed)

pdb ID (5xtd)