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Secondary structure is represented that alpha helicies are pink, beta sheets are yellow, and regions without secondary structure are white. Non protein structures are drawn in wireframe. Note the heme group with inhibitor bound (to be discussed later) CYP51 is known as cytochrome P450 14alpha -sterol demethylase. And is found in Mycobacterium tuberculosis. This enzyme removes the 14alpha -methyl group from sterol precursors.Podust LM, Poulos TL, Waterman MR. Crystal structure of
cytochrome P450 14alpha -sterol demethylase (CYP51) from
Mycobacterium tuberculosis in complex with azole inhibitors.
Biochemistry Mar, 13, 2001; 98(6): 3068-3073 1EA1(PDB) |
CYP51 In CPK Visualization Secondary structure is represented that alpha helicies are pink, beta sheets are yellow, and regions without secondary structure are white. Non protein structures are also drawn in CPK colored by atoms. Note how inaccessible the grey heme group is to the surface, visible though only two channels. Podust LM, Poulos TL, Waterman MR. Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Biochemistry Mar, 13, 2001; 98(6): 3068-3073 (PubMed) 1EA1 (PDB) |