An Interactive Jmol
Tutorial about Cytochrome P450:
James McCormick. 2014
Cytochrome P450 is a large group of enzymes that oxidize a wide range of
substrates. The most common reaction catalyzed is the addition of an oxygen
atom to the aliphatic position of an organic ligand, reducing the other
oxygen atom to water. The characteristic feature of cytochrome P450s is the
presence of a heme co-factor. These enzymes are critical for drug metabolism
and clearing, they are found in all forms of life. They are an important
factor for consideration when designing, testing, and administering
therapeutics.
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