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In the absence
of ligand EGFR dimerization is self-inhibited by burring the
dimerization arm between the two cysteine rich subdomains CS1
(green) and CS2 (red). Ferguson 2003 (1NQL)
Ligand binding
is mediated primarily by the L1 domain and exposes the
dimerization arm. Ogiso 2002 (1IVO)
The EGF
activated receptors can now dimerize and interact through
intermolecular disulfide bonds shown in gray. |