Solution structure of ubiquitin-like domain of human parkin

A single mutation that causes an Arg to Pro switch at position 42 has been identified in a number of autosomal recessive juvenile Parkinson's disease patients, however the function of this domain is not yet clear.
 Parkin ubiquitin-like domain R33Q mutant.  
NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domain.


Title of the reference :

Parkin binds the Rpn10 subunit of 26S proteosomes through its ubiquitin-like domain

Author :

Sakata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N., Mizuno, Y., Tanaka, K., Kato, K.

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PDB ID(PDB)

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