2P52

mouse p53 DNA-binding domain in zinc-free oxidized state

author(s): Kwon, E., Kim, D.Y., Suh, S.W., Kim, K.K.

Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors.

Citation
(PubMed)

2P52 (PDB)

4KVP

Human p53 Core Domain Mutant V157F

author(s): Wallentine, B.D., Wang, Y., Luecke, H.

Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.

Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined

mutation substitutes a smaller hydrophobic valine with a larger hydrophobic phenylalanine within strand S4 of the hydrophobic core. The structure of this cancer mutant shows no gross structural changes in the overall fold of the p53 core domain, only minor rearrangements of side chains within the hydrophobic core of the protein. Based on biochemical analysis, these small local perturbations induce instability in the protein, increasing the free energy.

Citation (PubMed)

4KVP(PDB)

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