3D09

Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

author(s): Rozenberg, H., Suad, O., Shakked, Z.

The tumor suppressor protein p53 is mutated in more than 50% of invasive cancers. About 30% of the mutations are found in six major "hot spot" codons located in its DNA binding core domain

R249S, the core domain incorporating R249S and a second-site suppressor mutation H168R

Citation
(PubMed)

3D09(PDB)

3D07

Human p53 core domain with hot spot mutation R249S (III)

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

its sequence-specific complex with DNA and of the triple mutant R249S/H168R/T123A.

The structural studies were accompanied by transactivation and apoptosis experiments of wt and several mutant-type conformations.

due to the loss of stabilizing interactions mediated by R249 in the wt protein.

author(s): Suad, O., Rozenberg, H., Shakked, Z.

Citation (PubMed)

3D07(PDB)

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