B-catenin interaction with E-cadherin

B-catenin was originally identified in cell adherens where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. (Xing)

B-catenin (gold) binds to the highly conserved cytoplasmic domain of cadherins (purple). Residues Phe118 (N-terminal) and Met149 (R1) are shown due their interaction with a-catenin. B-catenin (gold) residues 118-149 (N-term and R1) interaction with a-catenin (light purple) causing conformational change on R1. Spacefilling view showing the interaction E-cadherin (purple) with the armadillo domain (gold).

A conserved phosphorylation switch controls the interaction between Cadherin and B-catenin In vitro and In vivo
Choi HJ, Loveless T, Lynch AM, Bang I, Hardin J, Weis WI.
Dev. Cell (PubMed)

4R10 (PDB)

1DOW (PDB)