Residues interacting with Doxorubicin in the deep binding pocket of the monomer of the AcrB trimer. Binding of the substrate molecules is mainly achieved by aromatic stacking interactions and polar interactions by the indicated side chains .

Authors- Thomas Eicher, Hi-jea Cha, Markus A. Seeger, Lorenz Brandstätter, Jasmin El-Delik, Jürgen A. Bohnert, Winfried V. Kern, François Verrey, Markus G. Grütter, Kay Diederichs, and Klaas M. Pos
Title- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
2012 Apr 10;109(15):5687-92. doi: 10.1073/pnas.1114944109. Epub 2012 Mar 26 (PubMed)

4Dx7 (PDB)

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