Secondary
structure is represented in cartoon visualization that is in
color group.
Substrate dephosphorylation by PTEN, is dependent on the
C residue in Red
that acts as the thiol anion, this means that oxidation
reactions can cause deactivation of the catalytic activity. The
oxidation mechanism of inactivation, mostly occurs in the cell.
The ‘Reactive oxygen species (ROS),’ which are usually in form
of hydrogen peroxide are produced in the cell.
In this one is showing chain A is colored
blue and chain B is colored green.
The sulfurs of the cysteines are colored yellow.
Two disulfides form between the two chains. A third disulfide is
within Chain A.
The peroxides react with PTEN, resulting in the formation of a
disulphide bonding in the catalytic area. The bond is usually
formed between the amino acid residues C71 and C124. A compound
called peroxiredoxin I, usually protects the PTEN protein from
oxidation by peroxide.
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