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K27me3
usually binds within a hydrophobic pocket formed by three
aromatic residues, Tyr 26, Trp 47, and Trp 50. H3K27me3 is
shown in cyan and ball and stick model. TRP50, TRP47 and TYR26
are shown in fuchsia, red and green, respectively.
The
main-chain carbonyl and amino groups of Lys 23, Ala 24, Ala 25,
and Arg 26 of the H3K27me3 peptide make hydrogen bonds with dPC
residues 24–28 (located at the N terminus). H3K27me3 is shown in
cyan and ball and stick model. Lys 23, Ala 24 and Ala 25 of the
H3K27me3 peptide are shown in ball and stick model and green,
lime and lightseagreen, respectively. Tyr26, Ala 27, Ala 28 of
dPc are shown in ball and stick model and red, maroon and
tomato, respectively.
The
hydroxyl group of Ser 28 of histone H3 is involved in hydrogen
bonding to Glu 58 and Asn 62 of dPc. H3K27me3 is shown in cyan
and ball and stick model. Ser 28, Asn 62 and Glu 58 are shown in
ball and stick model and green, purple and red, respectively.
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