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MalFGK2 pre-translocation conformation with MBP. In this confirmational state, MBP is bound with maltose. This brings the NBDs closer to each other, allows ATP binding, and consequently causes MalK closure and TMD reorientation (outward-facing), leading to MBP opening. Structural basis for substrate specificity in the E. coli maltose transport system. Oldham, M.L., S. Chen, and J. Chen PNAS(PubMed) 4KHZ(PDB) |