1RV1

CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITO

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

Authors
Lukacs, C., Kammlott, U., Graves, B.
selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes.
These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice
IMZ( pocket intraction) C₃₁ H₃₄ Br₂ N₄ O₄
Journal (PubMed)

PDB ID (PDB)

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