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5AB9Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indoleExploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.AuthorsJoerger, A.C. The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers. different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography. 92O, ZN & PEG (pocket interaction) Journal (PubMed) PDB ID (PDB) Back to Table |