5AB9

Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.

Authors
Joerger, A.C.
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers.
different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography.

92O, ZN & PEG (pocket interaction)

Journal (PubMed)

PDB ID (PDB)

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