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The ~620 amino
acid extracellular region is composed of four subdomains: L1
(blue), CS1 (green), L2 (yellow), and CS2 (red).Ferguson 2003 (1NQL)
A single
transmembrane domain connects the receptor to the intracellular
tyrosine kinase domain. Barachov 2008 (2JWA)
Extracellular
activation causes formation of homodimers or heterdimers. This
brings cytosolic tyrosine kinase domains in close proximity and
allows for autophosphorylation. Stamos 2002 (1M17) |