BCRP Without Inhibitor

This is the structure of BCRP when not bound with inhibitor and in the relaxed, open-inward conformation.

This is the same structure used in previous pages.

 BCRP With Inhibitor

This is the structure when BCRP is bound with BWQ (C30 H41 N3 O5), an inhibitor.

Jackson, Scott M., et al. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat Struct Mol Biol. 2018 Apr;25(4):333-340. (This is the source for the previous page's image.) (PubMed)

6FFC (PDB)

Home |  Next page